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Also, see eMedicine's patient education articles Drug Dependence and Abuse and Substance Abuse .

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The DA agonist would also inhibit the firing of DA neurons by activating autoreceptors, thus precluding other salient stimuli reaching the basal ganglia.

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Thus, descending frontal projections may exert an inhibitory effect on striatal activity in DA projections or facilitate switching between behavioral alternatives.

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I'm not peculiar such an approach worked, tho, in the short-term.

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